By Alfred G. Knudson Jr. (auth.), Harry Harris, Kurt Hirschhorn (eds.)
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Additional info for Advances in Human Genetics 8
Whether environmental factors affect expression of the gene is also unknown. On the basis of the study of migrants, it is thought that environmental factors possibly dietary, rather than genetic factors account for the large difference in incidence of breast cancer between Orientals and Whites. 34 Digestive Tract Cancer Among cancers of the digestive tract, colorectal cancer is the one best known for its heritability, because of two dominant groups already discussed: the polyposis syndromes and the family cancer, or hereditary adenocarcinomatosis, syndrome.
At this time the quantitative contribution of each group cannot be assessed, but it appears that most cases will fall into the second or third group. Genitourinary Cancers Carcinoma of the body of the uterus has already been noted as a feature of the dominantly inherited family cancer syndrome. In addition, Lynch et al. 184 have called attention to families in which endometrial cancer is the principal tumor, although cancer can occur at other sites too. These pedigrees are consistent with dominant inheritance.
In order to distinguish this syndrome from that of pheochromocytoma and medullary carcinoma of the thyroid, Steiner73 proposed that the former be referred to as mUltiple endocrine neoplasia type 1 and the latter as type 2. The conditions are now generally known as mUltiple endocrine adenomatosis types 1 and 2 (MEA 1 and MEA 2). The islet cell tumors have been especially interesting because they are so common in MEA 1 and because they may be any of three types with respect to secretion: glucagon, insulin, or gastrin producing.
Advances in Human Genetics 8 by Alfred G. Knudson Jr. (auth.), Harry Harris, Kurt Hirschhorn (eds.)